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Analysis of synovial biopsy samples: opportunities and challenges
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It has become clear in recent years that the synovium is the
primary site of inflammation and a major effector organ in a variety of
joint diseases, including rheumatoid arthritis (RA). As a result, there
has been increased interest in studies of the pathological changes of
the synovium.1 There are, however, several caveats that
need to be recognised. Many of the older studies have examined synovial
tissue obtained at surgery. In these patients inflammation is not
necessarily a prominent feature. Moreover, patients requiring joint
surgery obviously represent a highly selective group, in whom specific
pathogenetic mechanisms may be operative that are associated with the
process of destruction. For instance, mutations in the tumour
suppresser gene p53 were demonstrated in fibroblast-like synoviocytes
from synovium of patients with RA with longstanding, destructive
disease.2 It has been suggested that the resulting loss of
p53 function may contribute to the autonomous progression of pannus
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Smith, M D, Baeten, D, Ulfgren, A-K, McInnes, I B, Fitzgerald, O, Bresnihan, B, Tak, P P, Veale, D, on behalf of the OMERACT synovial special interest,
(2006). Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go?. Ann Rheum Dis
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Koski, J M, Helle, M
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[Abstract] [Full Text]
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Immunology (including allergy)
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