Review
Treatment of oral dryness related complaints (xerostomia) in Sjögren's syndrome
Willy A van der Reijdena, Arjan Vissinkb, Enno C I Veermana, Arie V Nieuw Amerongena
a Section Oral
Biochemistry, Department of Oral Biology, Academic Centre for Dentistry
Amsterdam (ACTA), Amsterdam, the Netherlands, b Department of Oral and Maxillofacial Surgery,
University Hospital Groningen, Groningen, the Netherlands
Correspondence to: Dr W A van der Reijden, Section Clinical Oral Microbiology, Department of Oral Biology, Academic Centre for Dentistry Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands.
Accepted for publication 16 April 1999
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Primary Sjögren's syndrome (SS) is a systemic autoimmune disorder characterised by a chronic, progressive loss of salivary and lacrimal function resulting in symptoms of oral and ocular dryness. The involvement of exocrine glands is the result of a focal, periductal mononuclear cell infiltrate and the subsequent loss of secretory epithelial cells.1 As a consequence, major changes occur in both the salivary flow rate and salivary composition.2-9 In the case of secondary SS a second autoimmune disease is involved, mostly rheumatoid arthritis.
The role of saliva in maintaining oral health and even quality of life
is obvious in people who are lacking sufficient
saliva.10-12 The effects of the reduced salivary flow
rate (xerostomia) and changed salivary composition in SS are apparent
(table 1): there are problems in eating, speaking, and
swallowing12-15 and frequently disturbances in taste
perception.16 In addition, reduced clearance of food,
changes in microbial ecology and a reduced
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