Review
Immunological evaluation of cytokine and anticytokine immunotherapy in vivo: what have we learnt?
Immuno-rheumatology
Department, CHU Lapeyronie, 34295 Montpellier cedex 5 France
Correspondence to: Dr Jorgensen.
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Over the past five years, several immunotherapy trials have
been performed in autoimmune diseases by targeting interleukin 1
(IL1) (IL1 receptor antagonist (IL1-ra), IL-1 type I receptor), tumour necrosis factor (TNF
) (mAb anti-TNF, soluble receptor RTNFp55 or p75 fusion protein, TNF binding protein), interleukin 6 (IL6) or Th2 cytokines like recombinant human interleukin 10 (rhuIL10)
(table 1).1 One limitation of attempts to target a single
cytokine is the overlap of the immune effects of IL1, TNF, and IL6.
However, the clinical trials indicate that inhibition of a single
cytokine, despite the complexity of the network, is efficient.
Moreover, the inhibition of major cytokines involved in host defence
was found to be relatively well tolerated in the short-term, and few
infections were reported. Paradoxically, very few data are available
concerning effects of systemic delivery of rhuIL10 or cytokine
antagonist on the immune system. This review analyses the
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