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Building towards a consensus for the use of tumour necrosis factor blocking agents
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Over the past 10 to 15 years, scientific advances have
ushered in a new era in the treatment of rheumatoid arthritis. The aetiopathogenesis of rheumatoid arthritis is slowly being dissected and
an increased understanding of the mechanisms by which tissue damage
occurs in this disease is appearing.1 2 This knowledge, combined with the use of molecular technology, have begun to allow medical research to pinpoint potential targets for treatment of rheumatoid arthritis. Among such targets, you could include T cells,
macrophages, synoviocytes, the interaction between antigen presenting
cells and T cells, the MHC and its sub-units, and numerous cytokines
(for example, IL1, IL1ra, IL10, IL12, TNF
, etc).
This knowledge and technology have introduced a number of potential new
therapeutic agents. Earlier efforts using IL2 fusion proteins were
unfortunately unsuccessful.3 Various anti-CD4 monoclonal
antibodies have been tried to treat rheumatoid arthritis and some may
still be in development.4 Likewise, early trials of IL4,
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(2003). Infliximab Treatment of Rheumatoid Arthritis and Crohn's Disease. The Annals of Pharmacotherapy
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[Abstract] [Full Text] -
WEDDERBURN, L, PATEL, A, VARSANI, H, WOO;, P, VIGNOLA, S, SABATINI, F, FALCINI, F, PICCO, P, BUONCOMPAGNI, A, LOY, A, GATTORNO;, M, ALIKASIFOGLU, M, BAKKALOGLU, A, DUZOVA, A, BESBAS, N, TUNCBILEK, E, OZEN;, S, OZEN, S, UCKAN, D, BASKIN, E, BESBAS, N, SAATCI, U, BAKKALOGLU;, A, OZALTIN, F, BESBAS, N, UCAR, D, TUNCER, M, OZEN, S, TOPALOGLU, R, BAKKALOGLU;, A, SEELIGER, S, SUNDERKÖTTER, C, SORG, C, ROTH;, J, ROTH, J, FROSCH, M, STREY, A, WULFFRAAT, N, VOGL, T, SUNDERKÖTTER, C, KUIS, W, HARMS, E, SORG;, C, CRAWLEY, E., WOO;, P., FALCINI, F, MASI, L, SIMONINI, G, CALABRI, G., STAGI, S, BINDI, G, CIMAZ, R, BRANDI;, M., SEIBL, R., BIRCHLER, T., HOSSLE, J. P., BÜCHNER, K., LOELIGER, S., JEISY, E., GAY, R. E, SEGER, R. A, SAURENMANN, T., GAY, S., LAUENER;, R. P, BÜCHNER, K., BIRCHLER, T., SEIBL, R., HEUMANN, D., LOELIGER, S., HOSSLE, J. P., SEGER, R. A, LAUENER;, R. P, HAAS, J., FRANK, C, FERNANDEZ, S, ZURMÜHL, A, HERRMANN, M, RUDER;, H, THOMSON, W, SHELLEY, E, STEVENS, A, WORTHINGTON, J, OLLIER, W., DONN;, R., ZEGGINI, E, THOMSON, W, ALANSARI, A, OLLIER, W., DONN;, R., DONN, R., SHELLEY, E, OLLIER, W., THOMSON;, W, WOUTERS;, C, TEN CATE, R, FRENKEN, A., MELMAN, S, RAVENSBERGEN, E, TEN DAM, M, BRINKMAN, D., VAN TOL, M., NIBBERING;, P., MASSA, M, PASSALIA, M, VIOLA, S, DE BENEDETTI, F, PRAKKEN, B., MARTINI, A, ALBANI;, S, PIGNATTI, P, MEAZZA, C, VIVARELLI, M, MARTINI, A, DE BENEDETTI;, F, DE BENEDETTI, F, PIGNATTI, P, VIVARELLI, M, MEAZZA, C, SAVINO, R, CILIBERTO, G, MARTINI;, A, PRIGIONE, I, CHIESA, S, VIGNOLA, S, PICCO, P, BUONCOMPAGNI, A, PISTOIA, V, GATTORNO;, M, CARRASCO, S, HAYATA, A., KOCHEN, J., GOLGENSTEIN-SCHAINBERG;, C, FRENKE, J., HOUTEN, S. M, WATERHAM, H. R, WANDERS, R. J., DURAN, R., POLL-THE, B., KUIS;, W., GIRSCHICK, H., NANKI, T, GRAMMER, A, LIPSKY, P.
(2000). 1 Basic research. Ann Rheum Dis
59: 713a-719
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