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Parotid lipomatosis in HIV positive patients: a new clinical disorder associated with protease inhibitors
| The first 150 words of the full text of this article appear below. |
Protease inhibitors (PI) are a major advance in the treatment of HIV-1 infection. However, side effects of these drugs occur frequently.1 Abnormal fat accumulation in patients infected with HIV-1 has been described after starting treatment with PI.2 There might be several clinical disorders associated with fat deposition, namely increasing abdominal girth, abnormal dorsal cervical fat ("buffalo hump"), and hypertrophy of the breast.2-4 We report two cases of parotid fatty deposition associated with with retroviral treatment.
CASE 1 A 54 year old heterosexual
man with asymptomatic HIV infection of seven years duration was
referred with a two year history of painless growing bilateral parotid
swelling. He complained of dry mouth but not dry eyes. In June 1995 he
was taking zidovudine (1200 mg twice daily). From January 1996 he took
ritonavir monotherapy (600 mg twice daily). Four months later he
noticed bilateral parotid enlargement. After 12 months of ritonavir, he
was switched to lamivudine (150 mg twice
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