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Annals of the Rheumatic Diseases 1997;56:149-150; doi:10.1136/ard.56.3.149
Copyright © 1997 BMJ Publishing Group Ltd & European League Against Rheumatism.
Ann Rheum Dis 1997;56:149-150 ( March )

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The first 150 words of the full text of this article appear below.

    Introduction

Barely a century has passed since Gregor Mendel provided the explanation for inheritance and a foundation for what we now understand as genetics. Looking back it is perhaps even harder to believe that it is only just over 40 years on from Crick and Watson, who with coworkers determined the structure of DNA and cracked the genetic code. Given this comparatively short period of time, progress has been dramatic in all areas of genetics, but particularly so in medicine where we are now in an exponential phase of development and the profession is gradually realising that it is caught up in the spiral of a new genetic revolution.

Until recently medical genetics was relatively circumscribed and mainly concerned with rare monogenic conditions where the disease phenotype was often obvious or dramatic and the mode of inheritance known. Phenomenal recent progress in molecular biology has spawned molecular genetics and a new strain . . . [Full text of this article]


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