letter
Letter
Increased accumulation of advanced glycation endproducts in patients with Wegener’s granulomatosis
University Medical Center Groningen, Netherlands
Correspondence to: Karina de Leeuw, Internal Medicine, University Medical Center Groningen, PO Box 30.001, Groningen, 9700 RB, Netherlands; k.de.leeuw{at}int.umcg.nl
Accepted 11 October 2009
Wegener’s granulomatosis (WG) is a systemic autoimmune disease characterized by an increased risk for cardiovascular disease due to accelerated atherosclerosis, which cannot be fully explained by traditional risk factors.1 Therefore, non-traditional risk factors are probably involved. Among these, accumulation of advanced glycation endproducts (AGEs) might be important. AGEs are implicated in vascular pathology2 and are independent predictors of cardiovascular mortality in diabetic and hemodialysis patients.3;4
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