letter
Letter
TREX1 Gene Variant in Neuropsychiatric Systemic Lupus Erythematosus
Leiden University Medical Center, Netherlands
Correspondence to: Michel D Ferrari, LUMC, PO Box, Leiden, 0, Netherlands; m.d.ferrari{at}lumc.nl
Accepted 17 October 2009
Systemic lupus erythematosus (SLE) is an autoimmune disorder with a complex genetic background. Some 14-75% of SLE patients report neurological and psychiatric symptoms and are diagnosed with neuropsychiatric-SLE (NPSLE).1 Many of these patients also have cerebral white matter hyperintensities (WMH). The etiology and genetic background of NPSLE is largely unknown.
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