Ann Rheum Dis. Published Online First: 3 September 2007. doi:10.1136/ard.2007.075333
Concise Report |
Isolated knee monoarthritis heralding resectable non small-cell lung cancer. A paraneoplastic syndrome not previously described
1 Hospital of Prato, Italy
2 Arcispedale S Maria Nuova, Italy
* To whom correspondence should be addressed. E-mail: fcantini{at}usl4.toscana.it.
Accepted 14 May 2007
Abstract
Objective: To describe isolated knee monoarthritis as a paraneoplastic syndrome heralding non-small cell lung cancer (NSCLC), and to discuss its clinical characteristics.
Methods: We reviewed the clinical records of all consecutive, new outpatients with isolated knee monoarthritis observed from January 2000 to December 2005. A systematic review of Medline and Cochrane Library databases was performed to identify English-language articles related to rheumatologic paraneoplastic syndromes associated with NSCLC.
Results: Over 6 years, we observed 6654 new outpatients with different rheumatic disorders. Of these, 296 (4.4%) presented with isolated monoarthritis of the knee. In 5 out of 296 (1.7%) patients this feature represented the initial manifestation of NSCLC. All 5 patients were middle aged males, with a long history of heavy cigarette smoking, who had a nonerosive, isolated knee monoarthritis, with mild articular fluid collection of non inflammatory type. NSCLC was resectable in all patients, and knee monoarthritis remitted with no relapse confirming its paraneoplastic nature. All 5 patients are in good condition after a median follow up of 41 months. The literature review revealed that paraneoplastic knee monoarthritis has not been previously reported.
Conclusion: Knee monoarthritis may represent in some cases a paraneoplastic syndrome heralding NSCLC in an early stage.
Keywords: NSCLC early diagnosis, hypertrophic osteoarthropathy, knee monoarthritis, non small-cell lung cancer, rheumatic paraneoplastic syndromes
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- Is monoarthritis of the knee really a paraneoplastic syndrome?
- John P. Livoni MD, MPH
- Ann Rheum Dis Online, 11 Sep 2007 [Full text]
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