Annals of the Rheumatic Diseases 2009;68:412-415
CLINICAL AND EPIDEMIOLOGICAL RESEARCH
Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus
1 Centre for Paediatric Rheumatology, Ghent University Hospital, Ghent, Belgium
2 Department of Rheumatology, Université Catholique de Louvain, Louvain, Belgium
3 Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
4 Leids Universitair Medisch Centrum, Leiden, Netherlands
5 University College London, London, UK
6 Research Institute for Rheumatic Diseases, Piestany, Slovakia
7 Centre for Paediatric Rheumatology, University of Brussels, Brussels, Belgium
Dr D Elewaut, Ghent University Hospital, Department of Rheumatology, 185 De Pintelaan, B-9000 Ghent, Belgium; Dirk.Elewaut{at}UGent.be
Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies (ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).
Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae.
Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement.
Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.
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