Annals of the Rheumatic Diseases 2008;67:1570-1573
CLINICAL AND EPIDEMIOLOGICAL RESEARCH
Vitamin K in hand osteoarthritis: results from a randomised clinical trial
1 Boston University School of Medicine, Boston, Massachusetts, USA
2 Tufts Medical Center, Boston, Massachusetts, USA
3 USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Dr T Neogi: 650 Albany St, Clinical Epidemiology Unit, Suite X-200, Boston, MA 02118, USA; tneogi{at}bu.edu
Objectives: Vitamin K has bone and cartilage effects, and previously shown to be associated with radiographic osteoarthritis. We evaluated vitamin K’s effect on hand osteoarthritis in a randomised controlled trial.
Methods: This was an ancillary study to a randomised controlled trial assessing the effects of phylloquinone supplementation (vitamin K arm) versus placebo on bone loss and vascular calcification among older adults regardless of their vitamin K status. At the final 3-year study visit, we assessed the effects of vitamin K versus placebo on hand x-ray features of osteoarthritis using logistic regression and intention to treat, and also restricted analysis to the subgroup that had insufficient vitamin K concentrations at baseline.
Results: This ancillary study had 378 participants (193 in vitamin K arm, 185 in placebo arm). There were no effects of randomisation to vitamin K for radiographic osteoarthritis outcomes. Those with insufficient vitamin K at baseline who attained sufficient concentrations at follow-up had trends towards 47% less joint space narrowing (p = 0.02).
Conclusions: There was no overall effect of vitamin K on radiographic hand osteoarthritis. Subjects that were insufficient in vitamin K at baseline who attained sufficient concentrations at follow-up may have had a benefit in joint space narrowing. A clinical trial in those who are vitamin K insufficient may be warranted.
Trial registration number: NCT00183001.
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