Annals of the Rheumatic Diseases 2008;67:1505-1515
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Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
1 Wyeth Research, Cambridge, Massachusetts, USA
Dr Martin Hegen, Inflammation Discovery Research, Wyeth Research, 200 CambridgePark Drive, T5012K, Cambridge, MA 02140-2311, USA; mhegen{at}wyeth.com
Animal models of rheumatoid arthritis (RA) are widely used for testing potential new therapies for RA. However, the question of which animal model is most predictive of therapeutic efficacy in human RA commonly arises in data evaluation. A retrospective review of the animal models used to evaluate approved, pending RA therapies, and compounds that were discontinued during phase II or III clinical trials found that the three most commonly used models were adjuvant-induced arthritis (AIA) in rats and collagen-induced arthritis (CIA) in rats and mice. Limited data were found for more recently developed genetically modified animal models. Examination of the efficacy of various compounds in these animal models revealed that a compound’s therapeutic efficacy, rather than prophylactic efficacy, in AIA and CIA models was more predictive of clinical efficacy in human RA than data from either model alone.
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