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The epidemiology of ankylosing spondylitis and the commencement of anti-TNF therapy in daily rheumatology practice

¹ Ghent University, Ghent, Belgium
² University Hospital Sart Tilman, Liege, Belgium
³ University Hospital, Maastricht, Netherlands
⁴ University Hospital, Leuven, Belgium
⁵ Virga Jesse hospital, Hasselt, Belgium
⁶ Erasme University Hospital, Brussels, Belgium
⁷ Schering Plough, Brussels, Belgium

Correspondence to:
Correspondence to:
Bert Vander Cruyssen
Rheumatology Department, Ghent University Hospital, De Pintelaan 185, 90000 Ghent, Belgium; Bert.VanderCruyssen{at}Ugent.be

Objectives: This study aimed to describe the epidemiology of ankylosing spondylitis (AS) in rheumatology practice at the beginning of the anti-TNF (tumour necrosis factor) era, and to evaluate the initiation of anti-TNF therapy in a clinical setting where prescription is regulated by the authority’s imposed reimbursement criteria.

Methods: Between February 2004 and February 2005, all Belgian rheumatologists in academic and non-academic outpatient settings were invited to register all AS patients who visited their practice. A random sample of these patients was further examined by an in-depth clinical profile. In a follow-up investigation, we recorded whether patients initiated anti-TNF therapy and compared this to their eligibility at baseline evaluation.

Results: 89 rheumatologists participated and registered 2141 patients; 1023 patients were clinically evaluated. These 847 fulfilled the New York modified criteria for definite AS and 176 for probable AS. The profile of AS in rheumatology practice is characterised by longstanding and active disease with a high frequency of extra-articular manifestations and metrological and functional impairment. At a median of 2 months after the clinical evaluation, anti-TNF therapy was initiated in 263 of 603 (44%) evaluable patients with definite AS and in 22 of 138 (16%) evaluable patients with probable AS (total 38%). More than 85% of the patients who started anti-TNF therapy had an increased Bath Ankylosing Spondylitis Disease Activity Index despite previous NSAID (non-steroidal anti-inflammatory drug) use.

Conclusions: Of a representative cohort of 1023 Belgian AS patients seen in daily rheumatology practice, about 40% commenced anti-TNF therapy. Decision factors to start anti-TNF therapy may include disease activity and severity.

Abbreviations: AS, ankylosing spondylitis; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functionality Index; BASMI, Bath Ankylosing Spondylitis Metrology Index; CRP, C reactive protein; DMARDs, disease modifying antirheumatic drugs; IBD, inflammatory bowel disease; MTX, methotrexate; NSAID, non-steroidal anti-inflammatory drug; SpA, spondyloarthropathy; TNF, tumour necrosis factor

Keywords: ankylosing spondylitis; epidemiology; anti-TNF therapy; daily clinical practice

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				J. Braun and J. Sieper What is the most important outcome parameter in ankylosing spondylitis? Rheumatology, September 16, 2008; (2008) ken357v1. [Full Text] [PDF]