Annals of the Rheumatic Diseases 2005;64:1539-1541
HYPOTHESIS
Is progressive osteoarthritis an atheromatous vascular disease?
1 Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds UK
2 Leeds Musculoskeletal Service, Leeds UK
3 MRC Health Services Research Collaboration, University of Bristol, Bristol UK
Correspondence to:
Professor P G Conaghan
Academic Unit of Musculoskeletal Disease, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK; p.conaghan{at}leeds.ac.uk
Growing evidence from epidemiological studies suggests that osteoarthritis (OA) is linked to atheromatous vascular disease. This hypothesis article proposes that OA, or at least OA structural progression, may be an atheromatous vascular disease of subchondral bone. Further epidemiological studies, imaging investigations of relevant blood vessels, and trials of the effects of statins on the prevention and treatment of OA are needed to examine this hypothesis.
Abbreviations: MRI, magnetic resonance imaging; NSAIDs, non-steroidal anti-inflammatory drugs; OA, osteoarthritis
Keywords: osteoarthritis; atheromatous vascular disease; subchondral bone
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