REVIEW

Dendritic cells, Fc receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis

T R D J Radstake¹, A W T van Lieshout¹, P L C M van Riel¹, W B van den Berg¹, G J Adema²

¹ Department of Rheumatology, University Medical Centre Nijmegen, The Netherlands
² Department of Tumour Immunology laboratory, University Medical Centre Nijmegen, The Netherlands

Correspondence to:
Dr T R D J Radstake
Department of Rheumatology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands; t.radstake{at}reuma.umcn.nl

Recent findings suggest an important role for Fc receptors and Toll-like receptors expressed by dendritic cells (DC) in the pathogenesis of rheumatoid arthritis (RA). Possibly, DC behaviour might be tuned to counteract the misbalanced immune system in RA. Understanding the precise mechanisms that determine the skewed immune response in RA may provide new clues for the therapeutic use of DC in RA.

Abbreviations: APC, antigen presenting cell(s); CTA4Ig, T lymphocyte associated antigen 4 immunoglobulin; DC, dendritic cell(s); FCR, Fc receptor(s); HSP, heat shock protein(s); MHC, major histocompatibility complex; IC, immune complex(es); iDC, immature monocyte derived DC; IL, interleukin; IVIg, intravenous immunoglobulin; mDC, fully matured DC; RA, rheumatoid arthritis; TLR, Toll-like receptor(s); TNF, tumour necrosis factor

Keywords: dendritic cells; rheumatoid arthritis; Fc receptors; Toll-like receptors

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