REVIEW

Parasympathetic nervous system dysfunction in primary Sjögren’s syndrome

A Hoevar, M Tomi, S Praprotnik, M Hojnik, T Kveder, B Rozman

Department of Rheumatology, Medical Centre Ljubljana, SI 1000 Ljubljana, Slovenia

Correspondence to:
Correspondence to:
Professor B Rozman, Department of Rheumatology, Medical Centre Ljubljana, SI 1000 Ljubljana, Slovenia;
kc.lj.rozman{at}siol.net

In the past sicca syndromes were attributed to destruction of glandular tissue. It is now thought that cytokines, autoantibodies, and parasympathetic nervous system dysfunction all have an important role in the xerostomia and xerophthalmia in Sjögren’s syndrome.

Keywords: Sjögren’s syndrome; nerve system dysfunction

Abbreviations: ACh, acetylcholine; CAN, central autonomic network; MAChR, muscarinic cholinergic receptors; NO, nitric oxide; NOD, non-obese diabetic; SS, Sjögren’s syndrome

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