EXTENDED REPORT

Quality of life and work in patients with rheumatoid arthritis and ankylosing spondylitis of working age

A M J Chorus¹, H S Miedema², A Boonen³, Sj van der Linden³

¹ Division of Public Health, TNO Prevention and Health, Leiden, The Netherlands
² Netherlands Expert Centre for Work-Related Musculoskeletal Disorders, Erasmus University Hospital Rotterdam, The Netherlands
³ Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, The Netherlands

Correspondence to:
Correspondence to:
A M J Chorus
MSc, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands; AMJ.Chorus{at}pg.tno.nl

Objective: To investigate the relationship between work and quality of life (QOL) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) aged 16–59.

Methods: 1056 patients with RA and 658 with AS were included in the study. Data were obtained by postal questionnaire, which included several generic and disease related QOL instruments. Separate dimensions and physical and mental summary scores from the SF-36 were compared. Stepwise multiple regression was performed to study the relationship between work and physical and mental health related QOL, including disease related factors, coping, and fatigue.

Results: Physical health related QOL was reported to be worse, and mental health related QOL better, in RA than in AS in people of working age. No differences between RA and AS were found in somatic pain, physical role functioning, social functioning, emotional role functioning, vitality, or general health perception; nor were there any significant differences in fatigue and behavioural coping styles. Work was positively associated with physical health related QOL in both groups and, after disease characteristics, was the most important determinant. No association was found with mental health related QOL.

Conclusions: Although physical health related QOL was worse in patients with RA, the impact on several dimensions of health related QOL in patients with RA and AS of working age under rheumatological care was comparable. Patients with RA and AS experienced similar limitations in physical role functioning, including work. Work is an important independent external determinant of physical health related QOL, but not of mental health related QOL.

Keywords: rheumatoid arthritis; ankylosing spondylitis; work; quality of life

Abbreviations: ANCOVA, analysis of covariance; AS, ankylosing spondylitis; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; CORS, Coping with Rheumatic Stressors; MCS, mental component summary; MFI, Multidimensional Fatigue Inventory; PCS, physical component summary; QOL, quality of life; RA, rheumatoid arthritis; RADAI, Rheumatoid Arthritis Disease Activity Index; SDR, Standardised Diagnosis Register of Rheumatic Diseases; SF-36, Short Form-36

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Keat, A. (2009). Sex and the spondylitic. Rheumatology (Oxford) 48: 1337-1338 [Full Text]  
• LINDE, L., SORENSEN, J., OSTERGAARD, M., HORSLEV-PETERSEN, K., RASMUSSEN, C., JENSEN, D. V., HETLAND, M. L. (2009). What Factors Influence the Health Status of Patients with Rheumatoid Arthritis Measured by the SF-12v2 Health Survey and the Health Assessment Questionnaire?. The Journal of Rheumatology 36: 2183-2189 [Abstract] [Full Text]  
• Hamilton-West, K. E., Quine, L. (2009). Living with Ankylosing Spondylitis: The Patient's Perspective. J Health Psychol 14: 820-830 [Abstract]  
• Meijer, J. M., Meiners, P. M., Huddleston Slater, J. J. R., Spijkervet, F. K. L., Kallenberg, C. G. M., Vissink, A., Bootsma, H. (2009). Health-related quality of life, employment and disability in patients with Sjogren's syndrome. Rheumatology (Oxford) 48: 1077-1082 [Abstract] [Full Text]  
• Elewaut, D., Matucci-Cerinic, M. (2009). Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice. Rheumatology (Oxford) 48: 1029-1035 [Abstract] [Full Text]  
• Boonen, A., van Berkel, M., Kirchberger, I., Cieza, A., Stucki, G., van der Heijde, D. (2009). Aspects relevant for functioning in patients with ankylosing spondylitis according to the health professionals: a Delphi study with the ICF as reference. Rheumatology (Oxford) 48: 997-1002 [Abstract] [Full Text]  
• SINGH, J. A., STRAND, V. (2009). Spondyloarthritis Is Associated with Poor Function and Physical Health-Related Quality of Life. The Journal of Rheumatology 36: 1012-1020 [Abstract] [Full Text]  
• Verstappen, S M M, Jacobs, J W G, van der Heijde, D M, van der Linden, S., Verhoef, C M, Bijlsma, J W J, Boonen, A (2007). Utility and direct costs: ankylosing spondylitis compared with rheumatoid arthritis. Ann Rheum Dis 66: 727-731 [Abstract] [Full Text]