REVIEW

Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: a brief report and literature review

C Keller, A Webb, J Davis

University of California San Francisco, San Francisco, California, USA

Correspondence to:
Correspondence to:
Assistant Professor J C Davis
University of California San Francisco, 533 Parnassus Avenue, Box 0633, Room U383, San Francisco, CA 94143, USA; jdavis{at}medicine.ucsf.edu

Rheumatoid arthritis (RA) is a disease well characterised by proinflammatory cytokine secretion (particularly tumour necrosis factor, interferon gamma, interleukin (IL) 1, and IL6). Less has been reported about the cytokine profiling in the spondyloarthropathies (SpA). Several trials suggest that, similar to RA, proinflammatory cytokines are globally expressed in the SpA. However, other studies report a down regulation of these cytokines in the SpA, with a relative anti-inflammatory polarisation (featuring increases in IL4, IL5, and IL10). This review summarises current published reports and the variation in cytokine data in the SpA. Additionally, results of cytokine profiles in patients with ankylosing spondylitis before and after treatment with etanercept are reported.

Keywords: spondylitis; cytokines; tumour necrosis factor

Abbreviations: AS, ankylosing spondylitis; BASFI, Bath Ankylosing Spondylitis Functional Index; ELISA, enzyme linked immunosorbent assay; ESR, erythrocyte sedimentation rate; IFN, interferon gamma; IL, interleukin; LPLs, lamina propria lymphocytes; MEI, Modified Enthesopathy Index; OA, osteoarthritis; PBMCs, peripheral blood mononuclear cells; PMA, phorbol myristate acetate; PsA, psoriatic arthritis; RA, rheumatoid arthritis; RT-PCR, reverse transcriptase-polymerase chain reaction; SpA, spondyloarthropathies; TGF, transforming growth factor; TNF, tumour necrosis factor

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Baek, H. J., Zhang, L., Jarvis, L. B., Gaston, J. S. H. (2008). Increased IL-4+ CD8+ T cells in peripheral blood and autoreactive CD8+ T cell lines of patients with inflammatory arthritis. Rheumatology (Oxford) 47: 795-803 [Abstract] [Full Text]  
• Francois, R J, Neure, L, Sieper, J, Braun, J (2006). Immunohistological examination of open sacroiliac biopsies of patients with ankylosing spondylitis: detection of tumour necrosis factor {alpha} in two patients with early disease and transforming growth factor {beta} in three more advanced cases. Ann Rheum Dis 65: 713-720 [Abstract] [Full Text]  
• Duftner, C, Dejaco, C, Kullich, W, Klauser, A, Goldberger, C, Falkenbach, A, Schirmer, M (2006). Preferential type 1 chemokine receptors and cytokine production of CD28- T cells in ankylosing spondylitis. Ann Rheum Dis 65: 647-653 [Abstract] [Full Text]  
• Azuz-Lieberman, N., Markel, G., Mizrahi, S., Gazit, R., Hanna, J., Achdout, H., Gruda, R., Katz, G., Arnon, T. I., Battat, S., Zamir, E., Adawi, M., Mader, R., Mandelboim, O. (2005). The involvement of NK cells in ankylosing spondylitis. Int Immunol 17: 837-845 [Abstract] [Full Text]  
• Ostensen, M, Forger, F, Nelson, J L, Schuhmacher, A, Hebisch, G, Villiger, P M (2005). Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post partum. Ann Rheum Dis 64: 839-844 [Abstract] [Full Text]  
• Butrimiene, I., Jarmalaite, S., Ranceva, J., Venalis, A., Jasiuleviciute, L., Zvirbliene, A. (2004). Different cytokine profiles in patients with chronic and acute reactive arthritis. Rheumatology (Oxford) 43: 1300-1304 [Abstract] [Full Text]  
• Braun, J., Sieper, J. (2004). Biological therapies in the spondyloarthritides--the current state. Rheumatology (Oxford) 43: 1072-1084 [Abstract] [Full Text]  
• Dawes, P. T., Packham, J. C., Mucklow, J. C. (2004). TNF therapy for spondyloarthropathy: can we marshal the argument?. Rheumatology (Oxford) 43: 1069-1071 [Full Text]