© 2002 by Annals of the Rheumatic Diseases
REPORT
Is NF-
B a useful therapeutic target in rheumatoid arthritis?
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK
Correspondence to:
Correspondence to:
Professor M Feldmann;
m.feldmann{at}ic.ac.uk
There is increasing evidence that NF-
B is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-
B might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-
B blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-
B family.
Keywords: rheumatoid arthritis; nuclear factor
B
Abbreviations: APC, antigen presenting cell; DC, dendritic cells; ELISA, enzyme linked immunosorbent assay; GM-CSF, granulocyte macrophage colony stimulating factor; IKK2, I
B kinase 2; IL, interleukin; LPS, lipopolysaccharide; MHC, major histocompatibility complex; MMP, matrix metalloproteinase; m.o.i., multiplicity of infection; PBS, phosphate buffered saline; PSI, proteosome inhibitor; RA, rheumatoid arthritis; [3H]TdR, [3H]thymidine; TIMP, tissue inhibitor of matrix metalloproteinase; TNF
, tumour necrosis factor 
![]()
CiteULike
Complore
Connotea
Del.icio.us
Digg
Reddit
Technorati What's this?
This article has been cited by other articles:
-
Pattacini, L., Casali, B., Boiardi, L., Pipitone, N., Albertazzi, L., Salvarani, C.
(2007). Angiotensin II protects fibroblast-like synoviocytes from apoptosis via the AT1-NF-{kappa}B pathway. Rheumatology (Oxford)
46: 1252-1257
[Abstract] [Full Text] -
Amin, M. A., Haas, C. S., Zhu, K., Mansfield, P. J., Kim, M. J., Lackowski, N. P., Koch, A. E.
(2006). Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NF{kappa}B. Blood
107: 2252-2261
[Abstract] [Full Text] -
Pattoli, M. A., MacMaster, J. F., Gregor, K. R., Burke, J. R.
(2005). Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of I{kappa}B Kinase through Suppression of Metalloproteinase Expression. J. Pharmacol. Exp. Ther.
315: 382-388
[Abstract] [Full Text] -
Sweeney, S. E., Hammaker, D., Boyle, D. L., Firestein, G. S.
(2005). Regulation of c-Jun Phosphorylation by the I{kappa}B Kinase-{epsilon} Complex in Fibroblast-Like Synoviocytes. J. Immunol.
174: 6424-6430
[Abstract] [Full Text] -
Sacre, S. M., Andreakos, E., Feldmann, M., Foxwell, B. M.
(2004). Endotoxin signaling in human macrophages: signaling via an alternate mechanism. Innate Immunity
10: 445-452
[Abstract] -
Andreakos, E., Sacre, S. M., Smith, C., Lundberg, A., Kiriakidis, S., Stonehouse, T., Monaco, C., Feldmann, M., Foxwell, B. M.
(2004). Distinct pathways of LPS-induced NF-{kappa}B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP. Blood
103: 2229-2237
[Abstract] [Full Text] -
Monaco, C., Paleolog, E.
(2004). Nuclear factor {kappa}B: a potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc Res
61: 671-682
[Abstract] [Full Text]
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
