| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
REPORT |
B a useful therapeutic target in rheumatoid arthritis?
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK
Correspondence to:
Correspondence to:
Professor M Feldmann;
m.feldmann{at}ic.ac.uk
ABSTRACT
There is increasing evidence that NF-
B is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-B might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-B blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-B family.
Keywords: rheumatoid arthritis; nuclear factor B
Abbreviations: APC, antigen presenting cell; DC, dendritic cells; ELISA, enzyme linked immunosorbent assay; GM-CSF, granulocyte macrophage colony stimulating factor; IKK2, IB kinase 2; IL, interleukin; LPS, lipopolysaccharide; MHC, major histocompatibility complex; MMP, matrix metalloproteinase; m.o.i., multiplicity of infection; PBS, phosphate buffered saline; PSI, proteosome inhibitor; RA, rheumatoid arthritis; [3H]TdR, [3H]thymidine; TIMP, tissue inhibitor of matrix metalloproteinase; TNF
, tumour necrosis factor
This article has been cited by other articles:
|
|
 |
|
  L. Pattacini, B. Casali, L. Boiardi, N. Pipitone, L. Albertazzi, and C. Salvarani Angiotensin II protects fibroblast-like synoviocytes from apoptosis via the AT1-NF-{kappa}B pathway Rheumatology, August 1, 2007; 46(8): 1252 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Amin, C. S. Haas, K. Zhu, P. J. Mansfield, M. J. Kim, N. P. Lackowski, and A. E. Koch Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NF{kappa}B Blood, March 15, 2006; 107(6): 2252 - 2261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Pattoli, J. F. MacMaster, K. R. Gregor, and J. R. Burke Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of I{kappa}B Kinase through Suppression of Metalloproteinase Expression J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 382 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Sweeney, D. Hammaker, D. L. Boyle, and G. S. Firestein Regulation of c-Jun Phosphorylation by the I{kappa}B Kinase-{epsilon} Complex in Fibroblast-Like Synoviocytes J. Immunol., May 15, 2005; 174(10): 6424 - 6430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Sacre, E. Andreakos, M. Feldmann, and B. M. Foxwell Endotoxin signaling in human macrophages: signaling via an alternate mechanism Innate Immunity, December 1, 2004; 10(6): 445 - 452. [Abstract] [PDF]
|
|
|
|
|
|
E. Andreakos, S. M. Sacre, C. Smith, A. Lundberg, S. Kiriakidis, T. Stonehouse, C. Monaco, M. Feldmann, and B. M. Foxwell Distinct pathways of LPS-induced NF-{kappa}B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP Blood, March 15, 2004; 103(6): 2229 - 2237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Monaco and E. Paleolog Nuclear factor {kappa}B: a potential therapeutic target in atherosclerosis and thrombosis Cardiovasc Res, March 1, 2004; 61(4): 671 - 682. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
