REPORT

Is NF-B a useful therapeutic target in rheumatoid arthritis?

M Feldmann, E Andreakos, C Smith, J Bondeson, S Yoshimura, S Kiriakidis, C Monaco, C Gasparini, S Sacre, A Lundberg, E Paleolog, N J Horwood, F M Brennan, B M J Foxwell

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK

Correspondence to:
Correspondence to:
Professor M Feldmann;
m.feldmann{at}ic.ac.uk

There is increasing evidence that NF-B is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-B might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-B blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-B family.

Keywords: rheumatoid arthritis; nuclear factor B

Abbreviations: APC, antigen presenting cell; DC, dendritic cells; ELISA, enzyme linked immunosorbent assay; GM-CSF, granulocyte macrophage colony stimulating factor; IKK2, IB kinase 2; IL, interleukin; LPS, lipopolysaccharide; MHC, major histocompatibility complex; MMP, matrix metalloproteinase; m.o.i., multiplicity of infection; PBS, phosphate buffered saline; PSI, proteosome inhibitor; RA, rheumatoid arthritis; [³H]TdR, [³H]thymidine; TIMP, tissue inhibitor of matrix metalloproteinase; TNF, tumour necrosis factor

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