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Annals of the Rheumatic Diseases 2002;61:ii13-ii18
© 2002 by Annals of the Rheumatic Diseases


REPORT

Is NF-{kappa}B a useful therapeutic target in rheumatoid arthritis?

M Feldmann , E Andreakos , C Smith , J Bondeson , S Yoshimura , S Kiriakidis , C Monaco , C Gasparini , S Sacre , A Lundberg , E Paleolog , N J Horwood , F M Brennan , B M J Foxwell

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK

Correspondence to:
Correspondence to:
Professor M Feldmann;
m.feldmann{at}ic.ac.uk


ABSTRACT
There is increasing evidence that NF-{kappa}B is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-{kappa}B might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-{kappa}B blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-{kappa}B family.


Keywords: rheumatoid arthritis; nuclear factor {kappa}B

Abbreviations: APC, antigen presenting cell; DC, dendritic cells; ELISA, enzyme linked immunosorbent assay; GM-CSF, granulocyte macrophage colony stimulating factor; IKK2, I{kappa}B kinase 2; IL, interleukin; LPS, lipopolysaccharide; MHC, major histocompatibility complex; MMP, matrix metalloproteinase; m.o.i., multiplicity of infection; PBS, phosphate buffered saline; PSI, proteosome inhibitor; RA, rheumatoid arthritis; [3H]TdR, [3H]thymidine; TIMP, tissue inhibitor of matrix metalloproteinase; TNF{alpha}, tumour necrosis factor {alpha}




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