© 2002 by Annals of the Rheumatic Diseases
HYPOTHESIS
Could inflammatory arthritis be triggered by progenitor cells in the joints?
1 Immuno-rheumatology Department, INSERM U475, 34295 Montpellier, France
2 Osteogenesis Group, GBF (German Biotechnological Research Centre), Mascheroder Weg 1, 38124 Braunschweig, Germany
Correspondence to:
Correspondence to:
Dr C Jorgensen, Immuno-rheumatology Department, 34295 Montpellier, cedex 5, France;
jorgens{at}montp.inserm.fr
Fetal morphogenesis genes are expressed in rheumatoid synovial tissue and the presence of undifferentiated mesenchymal cells can also be shown. Possibly, these events are related to remodelling/repair processes, which could lead to the development of new methods of treatment, or they may be harmful and play a part in the immune process.
Keywords: inflammatory arthritis; progenitor cells; joints
Abbreviations: BMP, bone morphogenetic protein; FGF, fibroblast growth factor; IL, interleukin; NFAT, nuclear factor of activated T cells; PG, proteoglycan; RA, rheumatoid arthritis; rBMP, recombinant BMP; TGFß, transforming growth factor ß; Wnt, wingless
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