Concise report
Gastric antral vascular ectasia in systemic sclerosis:
complete resolution with methylprednisolone and cyclophosphamide
A R Lorenzi, A H Johnson, G Davies, A Gough
Department
of Rheumatology, Harrogate District Hospital, Harrogate, UK
Correspondence to: Dr A Gough, Department of Rheumatology, Harrogate District Hospital, Lancaster Road, Harrogate HG2 7SX, UK
Accepted for publication 17 November
2000
A case of severe, transfusion dependent anaemia in a 72 year
old woman, which on endoscopy was found to be due to gastric antral
vascular ectasia (GAVE), is reported. Repeated endoscopic sclerotherapy
was ineffective. She subsequently developed Raynaud's phenomenon and
on further investigation was found to have classical systemic sclerosis
with lung involvement. Treatment with pulses of intravenous
methylprednisolone and cyclophosphamide resulted in significant
improvement in her pulmonary function tests and skin score.
Coincidentally, her haemoglobin stabilised and further endoscopic
examinations were normal. This is the first report of cyclophosphamide
and methylprednisolone leading to complete and sustained resolution of
GAVE in association with systemic sclerosis.
© 2001 by Annals of the Rheumatic Diseases
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This article has been cited by other articles:
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SCHULZ, S. W., O'BRIEN, M., MAQSOOD, M., SANDORFI, N., GALDO, F. D., JIMENEZ, S. A.
(2009). Improvement of Severe Systemic Sclerosis-associated Gastric Antral Vascular Ectasia Following Immunosuppressive Treatment with Intravenous Cyclophosphamide. The Journal of Rheumatology
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[Abstract] [Full Text] -
Forbes, A., Marie, I.
(2009). Gastrointestinal complications: the most frequent internal complications of systemic sclerosis. Rheumatology (Oxford)
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[Abstract] [Full Text]
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