Extended report
Cofactor dependence and isotype distribution of anticardiolipin
antibodies in viral infections
H Guglielmonea b, S Vitozzia, O Elbarchaa, E Fernandeza
a Laboratorio de
Análisis Clínicos Especializados (LACE), Córdoba, Argentina, b Departamento de Bioquímica
Clínica, Facultad de Ciencias Químicas, Universidad Nacional de
Córdoba, Argentina
Correspondence to: Dr Guglielmone, Laboratorio de Análisis Clínicos Especializados (LACE), Av Velez Sarsfield 562-4to Piso, (5000) Córdoba, Argentina hgugli{at}bioclin.fcq.unc.edu.ar
Accepted for publication 12 September
2000
BACKGROUND
Antibodies
to cardiolipin (aCLs) are often detected in patients with autoimmune
disorders or infectious diseases.
OBJECTIVETo
investigate the distribution of aCL isotypes and requirement of protein
cofactor in viral infections in order to establish the importance, if
any, of these antibodies in these infectious diseases.
PATIENTS AND
METHODSThe isotype distribution of aCLs in the
sera from 160 patients with infection caused by HIV-1 (n=40), hepatitis
A virus (n=40), hepatitis B virus (n=40), or hepatitis C virus (n=40)
was studied by standardised enzyme linked immunosorbent assay (ELISA)
in the presence and absence of protein cofactor (mainly
2-glycoprotein I). Serum samples from healthy volunteers and
patients with syphilis and antiphospholipid syndrome were also included
and served as negative and positive control groups respectively.
RESULTSThe prevalence
of one or more aCL isotypes in serum of patients with HIV-1, hepatitis
A virus, hepatitis B virus, or hepatitis C virus infection was 47%,
92%, 42%, and 17% respectively (principally IgM and/or IgA). Most of
these antibodies were mainly cofactor independent.
CONCLUSIONSThe
presence of aCLs in viral infections is principally cofactor
independent, suggesting that cofactor dependence of the aCLs should be
assessed to distinguish subjects most likely to suffer from clinical
symptoms observed in the presence of these antibodies.
© 2001 by Annals of the Rheumatic Diseases
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