Extended report
Polymorphisms of the mannose binding lectin gene in patients with
Sjögren's syndrome
Z-Y Wang, A Morinobu, S Kanagawa, S Kumagai
Department of
Clinical and Laboratory Medicine, Kobe University School of Medicine,
Kobe, Japan
Correspondence to: Dr A Morinobu, Department of Clinical and Laboratory Medicine, Kobe University School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan morinobu{at}med.kobe-u.ac.jp
Accepted for publication 27 September
2000
OBJECTIVE
To
investigate polymorphisms of both codon 54 allele and promoter variants
of the mannose binding lectin (MBL) gene in patients with primary
Sjögren's syndrome (SS).
METHODSPolymorphisms
of codon 54 allele and promoter variants of the MBL gene in 104 patients with SS and 143 healthy controls were determined by polymerase
chain reaction-restriction fragment length polymorphism and allele
specific polymerase chain reaction respectively.
RESULTSThe allele
frequency of the wild type of MBL codon 54 was significantly higher in
patients with SS than in controls (0.836 v
0.741; p=0.011), and the frequency of the homozygous wild type of MBL
codon 54 was significantly higher in patients with SS than in controls
(0.692 v 0.539; p=0.024). On the other hand,
the allele frequencies of the MBL promoter gene did not differ between
patients and controls (
2=4.01, df=2, p=0.135).
CONCLUSIONThe
polymorphism of the MBL gene may be one of the genetic factors that
determines susceptibility to SS.
© 2001 by Annals of the Rheumatic Diseases
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