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An unexpected cause of muscle pain in diabetes
L Silberstein, K E Britton, F P Marsh, M J Raftery, D D'Cruz
St
Bartholomew's and the Royal London School of Medicine and Dentistry,
London, UK
Correspondence to: Dr D D'Cruz, The Lupus Research Unit, The Rayne Institute, St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, UK
Accepted for publication 20 October
2000
Diabetic muscle infarction is a rare condition which may
present to a rheumatologist. It was first reported in 1965. Two
illustrative cases are described here and the mechanisms of
pathogenesis discussed. Analysis of the published data, results of the
muscle biopsies, and a technetium-99m sestamibi scan suggest that the
condition, which occurs against a background of diabetic
microangiopathy, can be triggered by an ischaemic event and causes
extensive muscle necrosis through hypoxia-reperfusion injury and
compartment syndrome.
© 2001 by Annals of the Rheumatic Diseases
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