Extended report
Relative serum amyloid A (SAA) values: the influence of SAA1
genotypes and corticosteroid treatment in Japanese patients with
rheumatoid arthritis
T Yamadaa, Y Okudab, K Takasugib, K Itohc, J Igaria
a Department of
Clinical Pathology, Juntendo University School of Medicine, Tokyo,
Japan, b Centre
for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama, Japan, c Department of Clinical
Laboratory Medicine, Jichi Medical School, Tochigi, Japan
Correspondence to: Dr T Yamada, Department of Clinical Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan toshiyam{at}med.juntendo.ac.jp
Accepted for publication 7 June 2000
OBJECTIVES
(1) To
determine whether serum concentration of serum amyloid A (SAA) protein
is influenced by the SAA1 allele in Japanese patients with rheumatoid
arthritis (RA) as previously shown in a healthy control group; and (2)
to analyse what factors, based on such an allelic bias, influence the
relative SAA values of those patients.
METHODSSAA and C
reactive protein (CRP) concentrations together with SAA1 genotypes were
determined in 316 Japanese patients with RA. The relative SAA values
were evaluated as an SAA/CRP ratio.
RESULTSComparison of
the three SAA1 homozygote groups showed that the SAA/CRP ratio was
highest in the 1.5/1.5 group (mean 9.0, p<0.01 v the other two homozygote groups) followed
by the 1.3/1.3 group (mean 7.2, NS v the
1.1/1.1 group) and the 1.1/1.1 group (mean 4.0). The SAA/CRP ratio was
significantly higher in patients receiving corticosteroids regardless
of the presence of allele 1.5. No clear differences in the ratio
between patients with or without amyloidosis were found.
CONCLUSIONThe SAA1.5
allele and corticosteroid treatment had a positive influence on SAA
concentrations in serum. These findings are important when evaluating
SAA concentration in inflammatory diseases and when considering the
cause or treatment of amyloidosis.
© 2001 by Annals of the Rheumatic Diseases
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