Concise report
Difference in B cell activation between dermatomyositis and
polymyositis: analysis of the expression of RP105 on peripheral blood B
cells
Y Kikuchia, S Koaradaa, Y Tadaa, O Ushiyamaa, F Moritoa, N Suzukia, A Ohtab, T Horiuchid, K Miyakec, K Nagasawaa
a Department of
Internal Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga
849-8501, Japan, b Department of Nursing, Saga Medical School, c Department of Immunology, Saga
Medical School, d First
Department of Internal Medicine, Faculty of Medicine, Kyushu
University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Correspondence to: Dr Kikuchi kikuchi{at}post.saga-med.ac.jp
Accepted for publication 3 May 2001
BACKGROUND
It has
previously been shown that RP105, a new B cell surface protein, is lost
in activated human B cells.
OBJECTIVETo
investigate whether there is a difference in B cell activation between
patients with dermatomyositis (DM) and those with polymyositis (PM)
using RP105 as a marker.
METHODSThe population
of RP105 negative B cells (activated B cells) in the peripheral blood
mononuclear cells of seven patients with dermatomyositis (DM) and 11 with polymyositis (PM) was analysed by flow cytometry.
RESULTSThe percentage
of RP105 negative B cells in the peripheral blood of patients with PM
was low (5.8 (SD 2.4)%), similar to that of normal subjects. In
contrast, all patients with DM showed increased RP105 negative B cell
populations (33.0 (6.9)%). Bronchoalveolar lavage fluid from a patient
with DM and active interstitial pneumonitis contained a large number of
RP105 negative B cells.
CONCLUSIONThese
findings suggest that the expansion of RP105 negative B cells is a
hallmark of DM, and that B cell activation in DM may be
pathogenetically different from that in PM.
© 2001 by Annals of the Rheumatic Diseases
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