Extended report
Polymorphism in the vitamin D receptor gene and bone mass in
African-American and white mothers and children: a preliminary report
D A Nelsona, P J Vande Vordb, P H Wooleyb
a Department of
Internal Medicine, Wayne State University School of Medicine, Detroit,
Michigan, USA, b Department of
Orthopaedic Surgery, Wayne State University School of Medicine
Correspondence to: Dr Paul H Wooley, Department of Orthopaedic Surgery, WSU, Hutzel Hospital 1S, 4707 St Antoine Blvd, Detroit, MI 48201, USA Email: ad8754{at}wayne.edu
Accepted for publication 9 February 2000
OBJECTIVE
To evaluate
the contribution of polymorphisms in the vitamin D receptor (VDR) gene
to ethnic variations in bone mass in mother and children from different
ethnic origins.
METHODSVDR genotypes
and bone mass in 43 African-American and white women, mean age 38.2 years, and 41 of their children were studied. All children had a whole
body bone mass measurement at age 9, and 39 had follow up measurements
at age 11, while all the mothers had a single measurement. DNA was
extracted from peripheral blood samples, subjected to polymerase chain
reactions using primers specific for the VDR gene, and the
Bsm1 restriction fragment length polymorphism defined.
RESULTSThere was a
significant ethnic difference in the VDR genotype frequencies among the
adults and the children. No African-American subjects had the genotype
"BB". In contrast, there was a 25% frequency of the "BB"
genotype in the white adults and 24% in the white children. After
pooling the ethnic groups, the mean bone mass in the "bb" genotype
was significantly higher than in the "BB" genotype among the
mothers, but this was not found in the children at baseline. However,
by age 11, those with the "Bb" or "bb" genotypes had a larger
gain in bone mass than those with "BB".
CONCLUSIONThese data
support the suggestion that the ethnic difference in VDR genotype
frequencies, together with the association between the genotypes and
bone mass, may help to explain the well known ethnic differences in
bone mass. Further, our observations suggest that VDR polymorphism may
have an effect on bone mass during puberty as peak bone mass is accumulated.
© 2000 by Annals of the Rheumatic Diseases
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