Ann Rheum Dis 2000;59:583-586 ( August )

Review

Yttrium radiosynoviorthesis in the treatment of knee arthritis in rheumatoid arthritis: a systematic review Liesbeth L J Heuft-Dorenbosch^a, Henrica C W de Vet^b, Sjef van der Linden^a

^a Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, Maastricht, The Netherlands, ^b Institute for Research in Extramural Medicine, Vrije Universiteit Amsterdam, The Netherlands

Correspondence to: Dr Liesbeth Heuft-Dorenbosch, Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands Email: eheuf{at}sint.azm.nl

Accepted for publication 24 January 1999

OBJECTIVETo consider the question: How strong is the evidence in favour of yttrium synovectomy in chronic knee arthritis in patients with rheumatoid arthritis in comparison with placebo and intra-articular steroid treatment?
METHODSA systematic review of the literature was performed using Medline and the Embase database.
RESULTSInitially, seven papers were identified, but only two met the inclusion criteria. Neither study showed evidence in favour of yttrium synovectomy.
CONCLUSIONFrom the point of view of evidence based medicine it should be seriously questioned whether yttrium synovectomy deserves a place in clinical practice.

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© 2000 by Annals of the Rheumatic Diseases
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