Extended report
Soluble thrombomodulin concentration is raised in scleroderma
associated pulmonary hypertension
Richard J Strattona, Lucie Pompona, John G Coghlanb, Jeremy D Pearsonc, Carol M Blacka
a Academic
Rheumatology and Connective Tissue Disease Unit, The Royal Free
Hospital, Rowland Hill Street, London NW3 2PF, b Department of
Cardiology, The Royal Free Hospital, c Vascular Biology Research Centre, Kings College,
London
Correspondence to: Professor C M Black
Accepted for publication 1 October
1999
OBJECTIVE
To
investigate the expression of thrombomodulin in scleroderma associated
pulmonary hypertension.
METHODSSoluble
thrombomodulin (sTM), was measured in plasma samples from 34 scleroderma patients shown to have pulmonary hypertension at
echocardiogram, and comparison drawn against samples from 38 scleroderma control patients, and 20 healthy controls. Serial measurements of sTM were performed in the 34 patients with scleroderma associated pulmonary hypertension to investigate possible changes in
sTM concentration with progression of the condition.
RESULTSMean sTM was
raised in scleroderma associated pulmonary hypertension when compared
with scleroderma controls (mean sTM 65.4 ng/ml
v 43.3 ng/ml, p<0.05), and when compared
with healthy controls (mean sTM 38.1 ng/ml, p<0.05). There was no
significant difference between mean sTM in scleroderma controls and
healthy controls. Mean sTM concentration did not change with
progression of pulmonary hypertension.
CONCLUSIONPlasma
sTM is raised in scleroderma associated pulmonary hypertension. The
pathogenesis of scleroderma associated pulmonary hypertension may be
distinct from the pathogenesis of other forms of pulmonary vascular disease.
© 2000 by Annals of the Rheumatic Diseases
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