Ann Rheum Dis 2000;59:110-115 ( February )

Extended report

Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls Inge-Margrethe Gilboe^a, Tore K Kvien^a, Glenn Haugeberg^a, Gunnar Husby^b

^a Oslo City Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway, ^b Centre for Rheumatic Diseases, The National Hospital, Oslo, Norway

Correspondence to: Dr Gilboe

Accepted for publication 4 November 1999

OBJECTIVESTo examine bone mineral density (BMD) frequency of osteoporosis and reduced bone mass in systemic lupus erythematosus (SLE), and compare the data of the SLE patients with matched rheumatoid arthritis (RA) patients and healthy controls. Secondly, to study possible correlations between BMD, demographic and disease variables in the SLE patients.
METHODSMeasures of BMD assessed by dual energy x ray absorptiometry were obtained from 75 SLE patients aged  70 years, 75 RA patients matched for age, sex and disease duration, and from 75 healthy controls matched for age, sex and geographical area. Disease activity and accumulated organ damage were assessed in the SLE patients.
RESULTSThe SLE patients had significantly lower BMD values at lumbar spine L2-L4 and hip, and higher frequency of osteoporosis at all sites of measurement compared with matched healthy controls. The matched SLE and RA patients had similar BMD, prevalence of osteoporosis and reduced bone mass. In the SLE patients BMD was more strongly correlated with accumulated organ damage than with markers of disease activity or duration. In multivariate analyses BMD was at all sites predicted by age and body mass, at lumbar spine also by the current corticosteroid dose.
CONCLUSIONThe study showed reduced BMD in patients with SLE compared with matched healthy controls. Premenopausal women taking corticosteroids were especially affected. Furthermore, the BMD of matched SLE and RA patients was reduced to a similar extent.

---

© 2000 by Annals of the Rheumatic Diseases
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Mok, C., To, C., Ma, K. (2008). Changes in body composition after glucocorticoid therapy in patients with systemic lupus erythematosus. Lupus 17: 1018-1022 [Abstract]  
• Bertsias, G, Ioannidis, J P A, Boletis, J, Bombardieri, S, Cervera, R, Dostal, C, Font, J, Gilboe, I M, Houssiau, F, Huizinga, T, Isenberg, D, Kallenberg, C G M, Khamashta, M, Piette, J C, Schneider, M, Smolen, J, Sturfelt, G, Tincani, A, van Vollenhoven, R, Gordon, C, Boumpas, D T (2008). EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics. Ann Rheum Dis 67: 195-205 [Abstract] [Full Text]  
• Lilleby, V. (2007). Review: Bone status in juvenile systemic lupus erythematosus. Lupus 16: 580-586 [Abstract]  
• Almehed, K., Forsblad d'Elia, H., Kvist, G., Ohlsson, C., Carlsten, H. (2007). Prevalence and risk factors of osteoporosis in female SLE patients--extended report. Rheumatology (Oxford) 46: 1185-1190 [Abstract] [Full Text]  
• Lee, C., Almagor, O., Dunlop, D. D., Manzi, S., Spies, S., Chadha, A. B., Ramsey-Goldman, R. (2006). Disease damage and low bone mineral density: an analysis of women with systemic lupus erythematosus ever and never receiving corticosteroids. Rheumatology (Oxford) 45: 53-60 [Abstract] [Full Text]  
• Smerdel-Ramoya, A., Finholt, C., Lilleby, V., Gilboe, I.-M., Harbo, H. F., Maslinski, S., Forre, O., Thorsby, E., Lie, B. A. (2005). Systemic lupus erythematosus and the extended major histocompatibility complex--evidence for several predisposing loci. Rheumatology (Oxford) 44: 1368-1373 [Abstract] [Full Text]  
• Mok, C C, Mak, A, Ma, K M (2005). Bone mineral density in postmenopausal Chinese patients with systemic lupus erythematosus. Lupus 14: 106-112 [Abstract]  
• Di Munno, O, Mazzantini, M, Sedie, A D., Mosca, M, Bombardieri, S (2004). Risk factors for osteoporosis in female patients with systemic lupus erythematosus. Lupus 13: 724-730 [Abstract]  
• Pineau, C A, Urowitz, M B, Fortin, P J, Ibanez, D, Gladman, D D (2004). Osteoporosis in systemic lupus erythematosus: factors associated with referral for bone mineral density studies, prevalence of osteoporosis and factors associated with reduced bone density. Lupus 13: 436-441 [Abstract]  
• Peacock, M., Turner, C. H., Econs, M. J., Foroud, T. (2002). Genetics of Osteoporosis. Endocr. Rev. 23: 303-326 [Abstract] [Full Text]  
• Becker, A, Fischer, R, Scherbaum, W A, Schneider, M (2001). Osteoporosis screening in systemic lupus erythematosus: impact of disease duration and organ damage. Lupus 10: 809-814 [Abstract]  
• Chatham, W W, Kimberly, R P (2001). Treatment of lupus with corticosteroids. Lupus 10: 140-147 [Abstract]  
• Sen, D, Keen, R W (2001). Osteoporosis in systemic lupus erythematosus: prevention and treatment. Lupus 10: 227-232 [Abstract]