Hormone replacement therapy and patterns of osteoarthritis: baseline data from the Ulm Osteoarthritis Study

doi:10.1136/ard.59.2.105

Annals of the Rheumatic Diseases 2000;59:105-109; doi:10.1136/ard.59.2.105

Ann Rheum Dis 2000;59:105-109 ( February )

Extended report

Hormone replacement therapy and patterns of osteoarthritis: baseline data from the Ulm Osteoarthritis Study Andrea Erb^a, Hermann Brenner^a, Klaus-Peter Günther^b, Til Stürmer^a

^a Department of Epidemiology, University of Ulm, Germany, Helmholtzstr 22, D-89081 Ulm, Germany, ^b Department of Orthopaedic Surgery, University of Ulm

Correspondence to: Dr Erb

Accepted for publication 5 November 1999

OBJECTIVES $---$ It has been suggested that hormone replacement therapy (HRT) may protect against osteoarthritis (OA). The aim of this paperwas to assess the association between HRT and radiographicallydefined patterns ofOA.
METHODS $---$ 475 consecutive women aged 50 years or older (mean age 66.1) who underwent hip or knee joint replacement because of advancedOA in four hospitals in south west Germany were enrolled in across sectional study. Participants underwent a standardised interviewincluding detailed history of medication use and a physical examination.Furthermore, radiographs of the joint being replaced and of thecontralateral joint as well as of both hands were obtained. Patientswere categorised as having bilateral or unilateral OA accordingto the presence or absence of radiographic OA in the contralateraljoint. If radiographic OA of different hand and finger joint groupswas present, participants were categorised as having generalisedOA (GOA). Logistic regression was used to estimate odds ratiosand their 95% confidence intervals for the association betweenHRT and bilateral or GOA while adjusting for potentialconfounders.
RESULTS $---$ Fifty five women (11.6%) were using HRT. The median duration of use was 5.4 years. The prevalence of bilateral and GOA wassimilar among users of ORT (86.3% and 27.5%, respectively) andamong non-users of HRT (88.7% and 35.7%, respectively). Afteradjustment for potential confounding factors, the odds ratios(95% confidence intervals) of bilateral OA and GOA among HRT userscompared with non-users was 1.21 (0.48, 3.03) and 1.21 (0.53,2.74),respectively.
CONCLUSION $---$ Despite limited generalisability because of the selective study sample, these data do not support the hypothesis that HRTacts as a systemic protective factor againstOA.

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