Concise report
Procollagen IIC-peptide as a marker for assessing mechanical risk
factors of knee osteoarthritis: effect of obesity and varus alignment
T Kobayashia, Y Yoshiharaa, H Yamadab, K Fujikawaa
a Department of
Orthopaedic Surgery, National Defence Medical College, 3-2, Namiki,
Tokorozawa, Saitama, Japan, b Department of Orthopaedic
Surgery, Fujitaga Health University, Second Hospital, 3-6-10,
Bitoubashi, Nakagawa, Nagoya, Japan
Correspondence to: Dr T Kobayashi, Department of Orthopaedic Surgery, National Defence Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359-8513, Japan kyusei{at}me.ndmc.ac.jp
Accepted for publication 26 April 2000
OBJECTIVE
To ascertain
by cross sectional examination whether the concentration of procollagen
IIC-peptide in joint fluid significantly correlates with mechanical
risk factors of knee osteoarthritis (OA), such as obesity (body mass
index) and varus alignment (lateral femorotibial angle).
METHODSThe
concentrations of procollagen IIC-propeptide in synovial fluid were
measured by a sandwich enzyme immunoassay of 65 patients with the
same radiological stage of primary knee OAthat is, Ahlbäk stage I. The relations between procollagen IIC-peptide and body mass index and
lateral femorotibial angle were examined using simple regression
analysis and multiple regression analysis.
RESULTSSignificant
positive correlations were found between procollagen IIC-propeptide
concentrations and body mass index (r=0.479, p<0.0001), and between procollagen IIC-propeptide concentrations and
lateral femorotibial angle (r=0.375,
p=0.0021). Significant correlations were also found by multiple
regression analysis. The multiple correlation coefficient of body mass
index and femorotibial lateral angle to the procollagen
IIC-propeptide concentrations was 0.547 (p<0.0001).
CONCLUSIONSThe
findings suggest that synthesis of type II collagen by chondrocytes is
enhanced by abnormal mechanical stress, in this case obesity and varus
alignment. It is concluded that procollagen IIC-propeptide
concentrations in joint fluid are a useful marker of early OA.
© 2000 by Annals of the Rheumatic Diseases
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