Concise report
Increased level of apolipoprotein B/apolipoprotein A1 ratio as a
potential risk for osteonecrosis
Keita Miyanishi, Takuaki Yamamoto, Takahiko Irisa, Yasuo Noguchi, Yoichi Sugioka, Yukihide Iwamoto
Department of
Orthopaedic Surgery, Faculty of Medicine, Kyushu University, 3-1-1
Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Correspondence to: Dr T Yamamoto.
Accepted for publication 6 April 1999
OBJECTIVE
This study
was performed to investigate whether a high ratio of apolipoprotein B
to apolipoprotein A1 (apo B/apo A1 ratio) is significantly associated
with the risk of developing non-traumatic osteonecrosis of the femoral
head (ON).
METHODSFifty
consecutive non-traumatic ON cases were compared with 50 age and sex
matched controls, using both univariate and stepwise discriminant
analyses, regarding the factors of corticosteroid, alcohol, cigarettes,
cholesterol, triglyceride, and apo B/apo A1 ratio. To eliminate the
possibility that ON or osteoarthritic change itself can increase the
apo B/apo A1 ratio, a further 32 consecutive cases comprising nine
traumatic ON and 23 osteoarthritis (OA) patients were analysed using
Scheffe's test.
RESULTSThere was a
significant association between a high apo B/apo A1 ratio and the
development of non-traumatic ON with both univariate (p=0.0001) and
stepwise discriminant analyses (partial
r2=0.1239, p=0.0004). The apo
B/apo A1 ratio in the non-traumatic ON group was significantly higher
than that in the traumatic ON (p<0.01), control (p<0.001), or the OA
groups (p<0.001).
CONCLUSIONA high apo
B/apo A1 ratio is significantly associated with the risk of developing
ON. This ratio may be useful for assessing the potential risk of
developing osteonecrosis.
© 1999 by Annals of the Rheumatic Diseases
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