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Type II collagen is a target antigen of clonally expanded T cells
in the synovium of patients with rheumatoid arthritis
Taichi Sekinea b, Tomohiro Katoa, Kayo Masuko-Hongoa, Hiroshi Nakamuraa c, Shin-ichi Yoshinoc, Kusuki Nishiokaa, Kazuhiko Yamamotoa d
a Rheumatology,
Immunology and Genetics Program, Institute of Medical Science, St
Marianna University School of Medicine, Kanagawa, Japan, b Mitsubishi
Kagaku Bio-Clinical Laboratories Inc, Tokyo, Japan, c Division of Rheumatology, Nihon Medical School,
Tokyo, Japan, d Division
of Allergy and Rheumatology, University of Tokyo, Graduate School of
Medicine, Tokyo, Japan
Correspondence to: Dr T Kato, Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8512, Japan.
Accepted for publication 23 February 1999
OBJECTIVE
To
investigate whether type II collagen (CII) is recognised by
oligoclonally expanded synovial T cells of patients with rheumatoid arthritis (RA).
METHODSPeripheral
blood mononuclear cells (PBMC) from 15 RA patients were stimulated with
CII in vitro. T cell clones expanded by such stimulation were compared
with the clonally expanded synovial T cells by using T cell receptor
(TCR) B chain gene specific reverse transcription-polymerase chain
reaction and subsequent single strand conformation polymorphism analyses.
RESULTSStimulation of
the heterogeneous peripheral T cells with CII induced clonal expansion
of T cells. In three of 15 patients, a proportion of these clones
(approximately 17% to 25%) was found to be identical to expanded T
cell clones in the synovium in vivo.
CONCLUSIONT cell
clones that had TCR CDR3 sequences identical to those induced by
purified CII were found in a proportion of RA patients. This finding
suggests that CII is recognised by T cells that accumulate clonally in
RA joints. Oligoclonal T cell expansion in RA joints is probably
driven, at least in part, by intra-articular components such as CII.
© 1999 by Annals of the Rheumatic Diseases
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