Extended reports
Anti-inflammatory effects of systemic anti-tumour necrosis factor
treatment in human/murine SCID arthritis
Hiltrud Schädlicha, Jörg Ermanna, Maria Biskopb, Werner Falkc, Frauke Sperlinga, Astrid Jüngela, Jörg Lehmannd, Frank Emmricha, Ulrich Sacka
a Institute of
Clinical Immunology and Transfusion Medicine, University of Leipzig,
Germany, b Private Practice, Leipzig, Germany, c Department of Internal Medicine I,
University of Regensburg, Germany, d Immunology
Unit, Large Animal Medical Department, University of Leipzig,
Germany
Correspondence to: Correspondence to: Dr U Sack, Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Linnéstrasse 3, D-04103 Leipzig, Germany.
Accepted for publication 1 March 1999
OBJECTIVES
To evaluate
in vivo the contribution of tumour necrosis factor 
(TNF) to the
chimeric transfer model of human rheumatoid arthritis synovial membrane
into SCID mice (hu/mu SCID arthritis), systemic anti-TNF treatment
was performed and the clinical, serological, and histopathological
effects of this treatment assessed.
METHODSAnimals were
treated with the rat-antimouse TNF monoclonal antibody V1q, starting
on day 1 after hu/mu engraftment, twice weekly for 12 weeks. Joint
swelling, serum concentrations of human and murine interleukin 6 (IL6),
and serum amyloid P (SAP) were measured. Histopathological and
immunohistochemical analyses of the joints were also performed at the
end of treatment.
RESULTSNeutralisation
of murine TNF induced the following effects: (a) reduction of extent
and duration of the acute arthritis phase, with significant reduction
of joint swelling at two weeks; (b) decrease of murine SAP
concentrations after the first antibody administration; and (c)
increase of murine IL6 in the serum. At the end of treatment, there was
a significant reduction of the inflammatory infiltration in the
engrafted joints. Because of the mild degree of joint erosion, no
treatment effects could be demonstrated on the destructive process.
CONCLUSIONIn the
lymphocyte independent hu/mu SCID arthritis, anti-TNF treatment
reduces local and systemic signs of inflammation.
© 1999 by Annals of the Rheumatic Diseases
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