Concise reports
Examination of synovial fluid and serum hyaluronidase activity as
a joint marker in rheumatoid arthritis and osteoarthritis patients (by
zymography)
a Department of
Orthopaedic Surgery, Nagoya University school of Medicine, Nagoya,
Aichi, Japan, b Department of Biomolecular Engineering, Faculty
of Bioscience and Biotechnology, Tokyo Institute of Technology,
Yokohama, Japan, c Department of Orthopaedic Surgery, The Tokyo
Kosei Nenkin Hospital, Tokyo, Japan
Correspondence to: Dr H Nagaya, Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai-cho, syouwa-ku, Nagoya, Aichi 466-8550, Japan.
Accepted for publication 17 November 1998
OBJECTIVE
Hyaluronic
acid (HA) is an important joint marker and the substrate for
hyaluronidase (HAase). Synovial fluid (SF) and serum HAase were
measured to investigate the potential use of HAase as a joint marker in
rheumatoid arthritis (RA) and osteoarthritis (OA) patients.
METHODSThe subjects
were 39 patients with RA and 42 patients with OA. HAase activity was
measured by zymography and its relation with various parameters
examined statistically.
RESULTSIn RA SF
a positive correlation (r=0.458, p=0.0186)
was found between SF HAase activity and the concentration of serum C
reactive protein. A positive correlation
(r=0.45, p=0.024) was also found between SF
HAase activity and platelet count in the RA group. Serum HAase activity
in the RA group was significantly higher than in the OA group
(p<0.0001) and normal controls (p<0.0001).
CONCLUSIONThe results
suggest that SF HAase activity could be used as a marker of synovial inflammation.
© 1999 by Annals of the Rheumatic Diseases
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