Concise report
Detection of anti-ADAM 10 antibody in serum of a patient with
pulmonary fibrosis associated with dermatomyositis
Jiro Fujitaa, Tamotsu Takeuchib, Naomi Dobashia, Yuji Ohtsukib, Michiaki Tokudaa, Jiro Takaharaa
a First Department of
Internal Medicine, Kagawa Medical University, Kagawa, Japan, b Second Department of Pathology, Kochi Medical
School, Kochi, Japan
Correspondence to: Dr J Fujita, First Department of Internal Medicine, Kagawa Medical University, 1750-1, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Accepted for publication 21 July 1999
OBJECTIVES
It has been
suggested that the humoral immune system plays a part in the
pathogenesis of pulmonary fibrosis. Although circulating autoantibodies
to lung protein(s) have been suggested, few lung proteins have been
characterised. The purpose of this study is to determine the antigen
recognised by serum of a patient with pulmonary fibrosis associated
with dermatomyositis.
METHODSTo accomplish
this, anti-small airway epithelial cell (SAEC) antibody in a patient's
serum was evaluated using a western immunoblot.
RESULTSAn
autoantibody against SAEC was found, and the antigen had a molecular
weight of 62 kDa. Using the patient's serum, clones from the normal
lung cDNA library were screened and
demonstrated that anti-SAEC antibody in the patient's serum was
against ADAM (A disintegrin and metalloprotease) 10.
CONCLUSIONThis is the
first report that demonstrates the existence of anti-ADAM 10 antibody
in a patient with pulmonary fibrosis associated with dermatomyositis.
© 1999 by Annals of the Rheumatic Diseases
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