Concise report
A measure of limited joint motion and deformity correlates with
HLA-DRB1 and DQB1 alleles in patients with rheumatoid arthritis
Ann Cranneya, Rose Goldsteina, Ba' Phama, Marianna M Newkirkb, Jacob Karsha
a Department of
Medicine, University of Ottawa, Canada, b Department of Medicine, Montreal General
Hospital Research Institute, McGill University, Montreal, Canada
Correspondence to: Dr J Karsh, Ottawa Hospital-General Campus, 501 Smyth, Ottawa, Ontario, Canada K1H 8L6.
Accepted for publication 15 July 1999
OBJECTIVE
To assess
factors associated with a poor outcome in rheumatoid arthritis (RA), a
measure was developed of limited joint motion and deformity, a
deformity index (DI), and correlated biochemical and genetic variables
with the magnitude of the DI.
METHODSForty patients
were evaluated in a cross sectional study. Clinical measures included
the DI and Health Assessment Questionnaire, and disease variables
included the erythrocyte sedimentation rate, C reactive protein,
rheumatoid factor, and HLA-DRB1 and DQB1 alleles.
RESULTSSignificant
correlations were noted between increasing DI and duration of RA and
concentration of C reactive protein. Patients with a DQB1*301 allele or
DR4 allele had a higher DI than those without, and a positive trend was
noted between increasing DI and dose of DRB1 RA susceptibility alleles.
The trend was lost when a non-linear regression technique was used to
remove the effect attributable to C reactive protein, suggesting an
interrelation between persistent inflammation and genetics in
determining total joint damage.
CONCLUSIONSThe DI may
be useful to study interactions between genetic and inflammatory
processes in rheumatoid disease progression.
© 1999 by Annals of the Rheumatic Diseases
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Bunn, D. K., Shepstone, L., Galpin, L. M., Wiles, N. J., Symmons, D. P. M.
(2004). The NOAR Damaged Joint Count (NOAR-DJC): a clinical measure for assessing articular damage in patients with early inflammatory polyarthritis including rheumatoid arthritis. Rheumatology (Oxford)
43: 1519-1525
[Abstract] [Full Text] -
Zijlstra, T R, Bernelot Moens, H J, Bukhari, M A S
(2002). The rheumatoid arthritis articular damage score: first steps in developing a clinical index of long term damage in RA. Ann Rheum Dis
61: 20-23
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Genetics
-
Connective tissue disease
-
Musculoskeletal syndromes
-
Rheumatoid arthritis
-
Immunology (including allergy)
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
