Extended report
Ro/SSA and La/SSB specific IgA autoantibodies in serum of
patients with Sjögren's syndrome and systemic lupus erythematosus
Nader Pourmanda, Marie Wahren-Herleniusa, Iva Gunnarssona, Elisabet Svenungssona, Björn Löfströmb, Yiannakis Ioannouc, David A Isenbergc, Carl G M Magnussond
a Department of
Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, b Department of
Rheumatology, Mälar Hospital, Eskilstuna, Sweden, c Centre for
Rheumatology/ Bloomsbury Rheumatology Unit, Department of
Medicine, University College London, d Department
of Laboratory Medicine, Division of Clinical Immunology, Karolinska
Institutet, Stockholm, Sweden
Correspondence to: Dr N Pourmand, Department of Medicine, Rheumatology Unit, Centre of Molecular Medicine, Building L8:04, Karolinska Hospital, S-171 76 Stockholm, Sweden.
Accepted for publication 10 May 1999
OBJECTIVE
To
investigate the occurrence of IgA autoantibodies to Ro 52 kDa, Ro 60 kDa and La antigen in serum of patients with primary Sjögren's
syndrome (pSS) and systemic lupus erythematosus (SLE).
METHODSRecombinant Ro
52 kDa, Ro 60 kDa and La antigens were used to analyse autoantibodies
in serum from 25 patients with pSS, 30 patients with SLE and 20 controls using a semiquantitative immunoblotting approach.
RESULTSAmong the
patients with pSS, 21 (84%) had detectable IgA autoantibodies to Ro 52 kDa, 13 (52%) to Ro 60 kDa and 20 (80%) to La antigen. The
corresponding results for the patients with SLE were 22 (73%), 14 (47%) and 20 (67%), respectively. No IgA autoantibodies against the
three antigens were detected in 20 normal controls. A comparison of
several clinical features with the titres of IgA antibodies to Ro 52 kDa, Ro 60 kDa and La, revealed a significant relation between IgA
anti-Ro 52 and IgA anti-La to sicca (p< 0.05). Semiquantitative data
suggest that IgG is the dominating antibody to the three antigens
followed by IgM > IgA in both SLE and pSS patients. Specificity
studies of IgA autoantibodies with different subfragments of Ro 52 kDa
and Ro 60 kDa antigens showed that IgA antibodies did not differ from
IgG and IgM in their recognition pattern.
CONCLUSIONThese
results suggest that besides IgM and IgG, IgA autoantibodies are also
detected at high frequency in patients with pSS and SLE. Further
studies are necessary to evaluate the contribution of these IgA
autoantibodies to inflammation as well as their diagnostic value.
© 1999 by Annals of the Rheumatic Diseases
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