Concise reports
Salivary and serum hyaluronic acid concentrations in patients
with Sjögren's syndrome
Department of
Rheumatology, Tel Aviv-Souraski Medical Centre, Ichilov Hospital and
Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Correspondence to: Dr M Tishler, Department of Rheumatology, Tel Aviv-Souraski Medical Centre, Tel Aviv, Israel 64239.
Accepted for publication 1 June 1998
OBJECTIVE
To evaluate
salivary hyaluronic acid (HA) concentration in patients with primary
Sjögren's syndrome (SS).
METHODSSalivary and
serum HA concentrations were evaluated using a radiometric assay.
Thirty nine patients with SS served as the study group and their
results were compared with 19 patients having clinical symptoms and
signs of dry mouth and with 10 normal controls.
RESULTSSalivary HA
concentrations were significantly increased (p < 0.05) in the 39 patients with SS compared with the 19 patients with dry mouth and the
10 normal controls (240.7 (38.5) v 99.8 (14.6) and 91.3 (7.9) ng/ml, respectively) (mean (SEM)). No significant differences were noted in the serum HA concentrations between the three
groups (42 (3.9) v 36.3 (4.1) and 32 (4.3)
ng/ml, respectively) (mean (SEM)). No correlation could be found
between salivary HA concentrations and the focus score of lip biopsies,
nor between salivary HA concentrations and erythrocyte sedimentation
rate or other serological tests.
CONCLUSIONIncreased salivary HA
concentrations can serve as a marker of local inflammation and may be
of value in the diagnosis of SS.
© 1998 by Annals of the Rheumatic Diseases
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