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A study of the association of HLA DR, DQ, and complement C4
alleles with systemic lupus erythematosus in Iceland
a Department of
Internal Medicine, Division of Rheumatology, b Icelandic Centre for Rheumatology Research, c Department of Pathology, Immunogenetics Unit, d Department
of Immunology, e The Blood Bank, f Landspítalinn, National
University Hospital, Reykjavík, Iceland
Correspondence to: Dr K Steinsson, Department of Internal Medicine, Division of Rheumatology, Landspitalinn National University Hospital, 101 Reykjavik, Iceland.
Accepted for publication 23 June 1998
OBJECTIVE
To perform
an exploratory analysis of the relative contribution of single MHC
genes to the pathogenesis of systemic lupus erythematosus (SLE) in a
homogenous white population.
METHODSMHC class II
alleles and C4 allotypes were determined in 64 SLE patients and in
ethnically matched controls. HLA-DR and DQ typing was performed by
polymerase chain reaction amplification with sequence specific primers.
C4 allotypes were determined by agarose gel electrophoresis.
RESULTSThe frequency
of C4A*Q0 was significantly higher in patients than in controls (46.9%
v 25.3%, p=0.002). HLA-DRB1, DQA1, and DQB1
alleles in the whole group of SLE patients were not significantly different from those of controls. On the other hand increase in DRB1*03
was observed in the group of patients with C4A*Q0, as compared with
patients with other C4A allotypes (p=0.047). There was no significant
correlation between severe and mild disease, as judged by the SLEDAI,
and HLADR, DQ alleles and comparing the patients with C4A*Q0 with those
with other C4A allotypes there was no significant difference regarding
clinical manifestations.
CONCLUSIONThe
results are consistent with the argument that C4A deficiency
contributes independently to susceptibility and the pathogenesis of
SLE. C4A*Q0 in SLE patients in Iceland shows weaker linkage disequilibrium with DR3 genes than reported in most other white populations and emphasises the role of ethnicity.
© 1998 by Annals of the Rheumatic Diseases
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