Low frequency of recent parvovirus infection in a population-based cohort of patients with early inflammatory polyarthritis

doi:10.1136/ard.57.6.375

Annals of the Rheumatic Diseases 1998;57:375-377; doi:10.1136/ard.57.6.375

Ann Rheum Dis 1998;57:375-377 ( June )

Concise reports

Low frequency of recent parvovirus infection in a population-based cohort of patients with early inflammatory polyarthritis Beverley Harrison,^a Alan Silman,^a Elizabeth Barrett,^b Deborah Symmons^a

^a ARC Epidemiology Research Unit, Stopford Building, Oxford Road, Manchester M13 9PT, ^b Norfolk Arthritis Register, St Michael's Hospital, Aylsham, Norfolk

Correspondence to: Dr B J Harrison.

Accepted for publication 28 April 1998

OBJECTIVE $---$ To determine the contribution of human parvovirus B19 infection in explaining the incidence of early inflammatory polyarthritis(IP) in apopulation.
SETTING $---$ The Norfolk Arthritis Register (NOAR) is a community-based programme aiming to ascertain all new cases of IP arising in apopulation that lead to attendance at primarycare.
SUBJECTS $---$ 147 newly ascertained subjects with IP with a disease duration of less than 16weeks.
METHODS $---$ Full clinical appraisal of all subjects who were followed up for three years. B19 IgM assayed with a third generation antibodycapture enzymeimmunoassay.
RESULTS $---$ Only four (2.7%) patients had evidence of recent B19 infection, only one of whom did not satisfy criteria for rheumatoid arthritis(RA).
CONCLUSION $---$ B19 infection does not explain more than a small proportion of either RA or undifferentiated IP cases occurring in thepopulation.

Keywords: rheumatoid arthritis; epidemiology; human parvovirus B19

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