Ann Rheum Dis 1998;57:371-374 ( June )

Concise reports

A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study) I Meulenbelt,^a C Bijkerk,^c H S Miedema,^a F C Breedveld,^b A Hofman,^c H A Valkenburg,^d H A P Pols,^{c d} P E Slagboom,^a C M van Duijn^c

^a TNO Prevention and Health, Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, the Netherlands, ^b Department of Rheumatology and Department of Internal Medicine, University Hospital Leiden, the Netherlands, ^c Departments of Epidemiology and Biostatistics, ^d and Internal Medicine III, ^e Erasmus University Medical School, Rotterdam, the Netherlands

Correspondence to: Dr P E Slagboom, TNO Prevention and Health, Gaubius Laboratory, PO Box 2215, 2301 CE, Leiden, the Netherlands.

Accepted for publication 28 April 1998

OBJECTIVEA genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene.
METHODSSubjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene.
RESULTSThe IGF-1 locus was significantly associated with the presence of ROA (overall adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2).
CONCLUSIONThese results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.

Keywords: osteoarthritis; genetics; IGF-1

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© 1998 by Annals of the Rheumatic Diseases
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