Extended reports
Immunoglobulin allotype gene polymorphisms in systemic sclerosis:
interactive effect of MHC class II and KM genes on anticentromere
antibody production
a Division of Rheumatology,
Department of Medicine, Keio University School of Medicine, Tokyo,
Japan, b Department of Microbiology and Immunology, Medical University
of South Carolina, Charleston, USA, c Division
of Molecular Life Science, Department of Genetic Information, Tokai
University School of Medicine, Isehara, Japan
Correspondence to: Dr M Kuwana, Division of Rheumatology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Accepted for publication 18 May 1998
OBJECTIVE
To examine potential interactions
between immunoglobulin (Ig)allotype gene polymorphisms and
susceptibility to systemic sclerosis (SSc) as well as serological
expression in SSc patients.
METHODSIgG heavy chain allotypes G1M(f, z),
G2M(n+, n-), G3M(b, g) and Ig light chain allotype KM(1, (1, 2), 3)
were genotyped in 105 Japanese SSc patients and 47 race matched normal
controls using polymerase chain reaction (PCR) based methods.
Associations of each Ig allotype with SSc related antinuclear
antibodies were examined in combination with or without MHC class II alleles.
RESULTSGM/KM genotypic and allelic frequencies
were similar in SSc patients and in normal controls. Frequencies of
G1M(f) and G2M(n+) were significantly decreased in anticentromere
antibody (ACA) positive SSc patients compared with ACA negative SSc
patients (p = 0.04 and 0.02, respectively). Conversely, the presence of DQB1*0501 and KM(1, 2) significantly increased the risk of ACA positivity.
CONCLUSIONIg allotype gene polymorphisms were not
associated with susceptibility to SSc. Instead, the results suggested
that MHC class II and KM genes are associated with autoimmune responses
by interactively promoting the production of ACA.
© 1998 by Annals of the Rheumatic Diseases
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