Concise reports
Decreased serum apolipoprotein AII/AI ratio in systemic
amyloidosis
a Department of Clinical Pathology, Jichi Medical School,
Tochigi, Japan, b Department of
Clinical Laboratory Medicine, Toyama Medical and Pharmaceutical
University, Toyama, Japan, c Department of
Laboratory and Clinical Medicine, Fukui Medical School, Fukui , Japan, d Centre for Rheumatic Diseases,
Dohgo Spa Hospital, Matsuyama, Japan, e Department of Nephrology, Sendai Shakaihoken Hospital, Sendai,
Japan
Correspondence to: Dr T Yamada, Department of Clinical Pathology, Yakushiji, Minamikawachi, Tochigi 329-04, Japan.
Accepted for publication 27 February 1998
OBJECTIVE
To investigate if serum apolipoprotein
A-I and A-II (apoAI and apoAII) concentrations change in subjects with
systemic amyloidosis secondary to underlying disorders.
METHODSSerum concentrations of apoAI and apoAII
were measured in 21 multiple myeloma patients, including eight with
amyloidosis; 95 rheumatoid arthritis patients, including 45 with
amyloidosis; and 73 haemodialysis patients, including 32 with amyloidosis.
RESULTSApoAII values tended to be reduced in
subjects with amyloidosis in each group, but could not effectively
distinguish amyloidosis. However, apoAII/AI ratios were significantly
lower in subjects with amyloidosis in all groups. The ratio of 0.2 had
diagnostic sensitivity and specificity for amyloidosis; 50% and 100%,
respectively, in multiple myeloma; 80% and 78%, respectively, in
rheumatoid arthritis; and 46% and 90%, respectively, in patients
requiring long term haemodialysis.
CONCLUSIONThe apoAII/AI ratio can be a useful
biochemical marker of suspect amyloidosis in patients with underlying
diseases, especially those with rheumatoid arthritis.
© 1998 by Annals of the Rheumatic Diseases
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