Concise reports
Inactivation of antithrombin III in synovial fluid from patients
with rheumatoid arthritis
a Department of
Rheumatology, Royal Hampshire County Hospital, Winchester, b Inflammation Research Group, St
Bartholomew's and the Royal London School of Medicine and Dentistry,
London, c Department of Rheumatology,
Christchurch Hospital, Christchurch
Correspondence to: Dr H W Jones, Clinical Rheumatology Unit, Guy's Hospital, London SE1 9RT.
Accepted for publication 21 January 1998
OBJECTIVE
To investigate the thrombin inhibitory
capacity of antithrombin III in the inflamed human joint.
METHODSThrombin inhibitory capacity was measured,
using a kinetic spectophotometric method, in matched plasma and
synovial fluid samples of patients with rheumatoid arthritis (n=22) and
osteoarthritis (n=16), together with normal control plasma samples
(n=13). In the same samples, the concentration of antithrombin III was
also determined by the method of radial immunodiffusion. The
combination of these measurements allowed the calculation of the
specific thrombin inhibitory capacity of these samples.
RESULTSAn increased concentration of antithrombin
III in rheumatoid compared with osteoarthritic synovial fluid was noted
(p<0.05). However, there was a significant depression in the specific
activity of antithrombin III in rheumatoid synovial fluid when compared with matched plasma samples (p<0.001) or with osteoarthritic synovial fluid (p<0.05).
CONCLUSIONIn rheumatoid synovial fluid the
thrombin inhibitory capacity of antithrombin III is disproportionately
depressed relative to the concentration of antithrombin III, indicating
the inactivation of antithrombin III in the rheumatoid joint.
© 1998 by Annals of the Rheumatic Diseases
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Chang, X., Yamada, R., Sawada, T., Suzuki, A., Kochi, Y., Yamamoto, K.
(2005). The inhibition of antithrombin by peptidylarginine deiminase 4 may contribute to pathogenesis of rheumatoid arthritis. Rheumatology (Oxford)
44: 293-298
[Abstract] [Full Text] -
Braat, E A M, Jie, A F H, Ronday, H K, Beekman, B, Rijken, D C
(2000). Urokinase-mediated fibrinolysis in the synovial fluid of rheumatoid arthritis patients may be affected by the inactivation of single chain urokinase type plasminogen activator by thrombin. Ann Rheum Dis
59: 315-318
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Immunology (including allergy)
-
Connective tissue disease
-
Degenerative joint disease
-
Musculoskeletal syndromes
-
Rheumatoid arthritis
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
