Extended reports
Analysis of T cell subsets present in the peripheral blood and
synovial fluid of reactive arthritis patients
University of Cambridge School of Clinical Medicine,
Department of Medicine, Box 157, Level 5, Addenbrooke's Hospital,
Hills Road, Cambridge, CB2 2QQ
Correspondence to: Dr Beacock-Sharp.
Accepted for publication 13 January 1998
OBJECTIVE
Reactive arthritis (ReA), a
HLA-B27 associated arthropathy, develops in susceptible people after
infection with certain bacteria. T cells have been implicated in the
pathogenesis of the arthritis but which of the different subsets is
involved is still debated. This study has further elucidated the role
of the CD4+ and CD8+ T cells by examining the
expression of various surface markers associated with activation.
METHODSThree colour flow cytometry was used to
examine the phenotype of the T cells within the synovial fluid (SF) and
peripheral blood (PB) of ReA patients.
RESULTSReA SF, compared with paired PB, contained
a higher percentage of CD69+, CD25+, and
HLA-DR+ CD3+ T cells. The majority of SF T
cells also expressed the putative memory marker CD45RO. Within the T
cell subsets, CD25 was expressed primarily on the CD4+ T
cells; however more CD8+ T cells were HLA-DR+.
CONCLUSIONThe results show that both
CD4+ and CD8+ T cell populations demonstrate
evidence of recent activation. Whether these cells are involved in
inducing inflammation, regulating the inflammation, or have become
active as a result of migration through the endothelium, remains to be
determined by functional studies.
© 1998 by Annals of the Rheumatic Diseases
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