Concise reports
Analysis of T cell receptor V alpha polymorphisms in rheumatoid
arthritis
a Rheumatology Unit, Royal
Postgraduate Medical School, Hammersmith Hospital, London, b Service de Rhumatologie, CHUV,
Lausanne, Switzerland, c Division de Rhumatologie, HCUG, Geneva, Switzerland, d Division d'Immunologie et
d'Allergologie, HCUG, Geneva, Switzerland, e Molecular Immunogenetics Unit, UMDS, Guy's Hospital, London, f Molecular Immunology Group, Institute of
Molecular Medicine, John Radcliffe Hospital, Oxford, g Department of Rheumatology, University Hospital of
Wales, Cardiff
Correspondence to: Professor A K So, Service de Rhumatologie, CHUV, 1011 Lausanne, Switzerland.
Accepted for publication 13
November 1997
OBJECTIVE
To test for association of T cell
receptor (TCR) V alpha polymorphisms and rheumatoid arthritis (RA) in
British and Swiss white populations.
METHODSTCRAV polymorphisms were analysed in RA
patients and controls by single strand conformational polymorphism
(SSCP) analysis. Associations were sought between defined genotypes and
RA, and the effect of HLA-DR4 status analysed. Putative associations
were then retested further in new groups of patients and controls. Overall, 360 RA patients and 197 controls were studied.
RESULTSNo association between TCRAV5S1, V6S1,
V8S1, V17S1 or V21S1 polymorphisms and RA were observed in the initial
population screened. Stratification for DR4 status showed an increase
of V5S1*01/*01 in DR4 positive versus DR4 negative patients
(
2 = 7.19, p=0.028 (2df), p=0.14 after correction for
multiple comparisons). This putative association was tested in three
further patient groups, none of which showed significant increase of
V5S1*01/*01 in DR4 positive patients, although an overall trend towards
an increase in V5S1*01/*01 was observed.
CONCLUSIONNo evidence was found for a strong
association of TCRAV genes and RA in a white population. However, these
results suggest a weak association of V5S1*01/*01 with DR4 positive RA,
although this requires confirmation using larger groups of patients and controls.
© 1998 by Annals of the Rheumatic Diseases
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Moffatt, M. F., Traherne, J. A., Abecasis, G. R., Cookson, W. O. C. M.
(2000). Single nucleotide polymorphism and linkage disequilibrium within the TCR {alpha}/{delta} locus. Hum Mol Genet
9: 1011-1019
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Immunology (including allergy)
-
Connective tissue disease
-
Degenerative joint disease
-
Musculoskeletal syndromes
-
Rheumatoid arthritis
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
