Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis

doi:10.1136/ard.56.8.500

Annals of the Rheumatic Diseases 1997;56:500-503; doi:10.1136/ard.56.8.500

Ann Rheum Dis 1997;56:500-503 ( August )

Concise reports

Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis Tatsuo Kobayashi,^a Yasuo Yoshihara,^a Atsuyoshi Samura,^a Harumoto Yamada,^a Masayuki Shinmei,^*^a Harald Roos,^b L Stefan Lohmander^b

^a Department of Orthopaedic Surgery, National Defence Medical College, Tokorozawa, Japan , ^b Department of Orthopaedics, University Hospital, S-221 85 Lund, Sweden

Correspondence to: Dr T Kobayashi, Department of Orthopaedic Surgery, National Defence Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359, Japan.

Accepted for publication 13 May 1997

OBJECTIVE $---$ To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index(BMI), disease stage, and the concentrations of a putative jointfluid marker of type II collagen synthesis, procollagen II C-propeptide.
PATIENTS AND METHODS $---$ The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrationsin synovial fluid of procollagen II C-propeptide were measuredby a sandwich enzymeimmunoassay.
RESULTS $---$ Joint fluid concentrations of procollagen II C-propeptide were increased in knees with OA (median 3.7 ng/ml), compared withpublished reference values for knees in healthy adult volunteers(median 1.3 ng/ml). The concentrations of procollagen II C-propeptidewere independently related to both OA stage and BMI (r_s = 0.343,p < 0.0001 and r_s = 0.253, p = 0.002,respectively).
CONCLUSIONS $---$ Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decreasein end stage disease. In addition and for the first time it wasshown that the concentrations in synovial fluid of procollagenII C-propeptide increase with increasing BMI in primary knee OA.The increased joint fluid values of this marker in patients withprimary knee OA and a high BMI, may reflect increased rates ofcollagen synthesis in their joint cartilage and could relate tothe previously shown increased risk for disease progression insuchpatients.

^* Dr Shinmei isdeceased.

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