Extended reports
The LMP2 polymorphism is associated with susceptibility to acute
anterior uveitis in HLA-B27 positive juvenile and adult Mexican
subjects with ankylosing spondylitis
a Departments of Medicine , b and Public Health Sciences , c University of Alberta, Canada Rheumatology Unit, Hospital General de
Mexico, Mexico City, d Department
of Immunogenetics, INDRE, SSA, Mexico City , e Centro de Investigacion
Biomedica, IMSS, Guadalajara , f Department of Rheumatology, Hospital de Especialidades
CMNO, IMSS, Guadalajara, Mexico
Correspondence to: Dr W P Maksymowych, 562 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.
Accepted for publication 6
June 1997
INTRODUCTION
An association between polymorphism
of the HLA linked LMP2 locus and the development of acute anterior
uveitis (AAU) has previously been described in B27 positive white
subjects with ankylosing spondylitis (AS). This study evaluated LMP2
alleles in two HLA-B27 positive Mexican populations of patients with
spondyloarthropathy known to have a different clinical spectrum of
disease from white people.
PATIENTS AND METHODSThe study populations
consisted of 90 AS patients from Guadalajara with predominantly adult
onset disease and 80 AS patients from Mexico City with predominantly
juvenile onset disease. LMP2-CfoI amplified fragment length
polymorphisms were determined after polymerase chain reaction
amplification and digestion with CfoI restriction enzyme.
RESULTSThere was an increased LMP2A allelic
frequency in patients who had had AAU in both Guadalajara (31.8%) and
Mexico City (33.3%) when compared with non-AAU patients (15.2% and
17.7% of Guadalajara and Mexico City populations, respectively). The
odds ratio relating LMP2A allelic frequency and AAU for the combined
population, stratified by age at onset of disease, was 2.51 (p=0.01).
LMP2 alleles did not influence the age at onset of disease or the
development of peripheral arthritis.
CONCLUSIONSThese data support the view that
polymorphism at the LMP2 locus is associated with the development of
AAU in B27 positive subjects with AS. The requirement for both the less
common LMP2 allele and HLA-B27 is consistent with the low prevalence of
AAU in Mexican patients with spondyloarthritis.
© 1997 by Annals of the Rheumatic Diseases
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